Dear Friends! Welcome to our website! Our research group is actively working in organic synthesis and medicinal chemistry. Our primary research focuses on cool projects like a practical stereo-selective total synthesis of complex biologically potent natural products and medicinal chemistry. We investigate to preparation more powerful, less toxic, and structurally simplified analogs of various complex natural products via structural modification of natural parent molecules. We also work on developing new synthetic methodologies involving π-activation induced cycloisomerization of alkynes and cascade polycyclizations. 

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Natural products have long been regarded as ‘nature’s medicine chest,’ providing a rich source of lead compounds as invaluable platforms for developing front-line drugs. 63% of all new drugs approved by the FDA between 1981 and 2006 were inspired by natural products. Our research focuses on making and modifying naturally occurring bioactive compounds that have been isolated from plants, animal tissue, microbes, or marine and soil organisms, which are rare or hard to isolate in abundance. These compounds provide rich and diverse chemical structures that challenge the synthetic chemist to develop a new flexible synthetic methodology for their construction. Preparing synthetic analogs of the natural compound may improve biological activity and provide an understanding of the mechanism of action of the naturally occurring compound.