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Publications

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  1. Ramavath Vinodkumar, Ashwini K. Nakate, Gamidi Rama Krishna, Ravindar Kontham. Ready Access to [5,6,5] - Trioxa-spiro and Fused Ketals via Ag-Catalyzed Cascade Annulation of 4-Pentyn-1-ols and Aldehydes Org.Lett. 2024. https://doi.org/10.1021/acs.orglett.4c02357.

  2. Ramavath Vinodkumar, Ashwini K. Nakate, Himanshu Sharma, Kumar Vanka, Gamidi Rama Krishna, Ravindar Kontham. Brønsted Acid-Promoted Cyclodimerization of α,β-Unsaturated γ‑Ketoesters: Construction of Fused Pyrano-ketal-lactones and γ‑Ylidene-butenolides. ACS Omega 2024, 9, 19859−19878. DOI: https://doi.org/10.1021/acsomega.3c08873.

  3. Shubhranshu Shekhar Sahoo, Priyanka Kataria, Ravindar Kontham. Concise and collective total syntheses of 2,4-disubstituted furan-derived natural products from hydroxyoxetanyl ketones. Org. Biomol. Chem., 2024, 22, 1475. DOI: 10.1039/d3ob01924a.

  4. Ashwini K. Nakate, Priyanka Kataria, Pooja I. Sambherao, Gamidi Rama Krishna, Ravindar Kontham. Divergent access to polycyclic spiro- and fused-N,O-ketals through Bi(OTf)3-catalyzed [4+2]-annulation of cyclic N-sulfonyl ketimines and alkynols. Chem. Commun., 2024, 60, 1144. DOI: 10.1039/d3cc05599j.

  5. Gopal S. Kallure, Shubhranshu Shekhar Sahoo, Rutuja S. Kale, Vitthal T. Barvkar, Ravindar Kontham, Ashok P. Giri. Aminoacylase efficiently hydrolyses fatty acid amino acid conjugates of Helicoverpa armigera potentially to increase the pool of glutamine Insect Biochemistry and Molecular Biology 165 (2024) 104070. DOI: https://doi.org/10.1016/j.ibmb.2024.104070.

  6. Akshay B. Rathod, Balasaheb R. Borade,Pooja I. Sambheraoa. Bi(OTf)3-promoted cascade annulation of hydroxy-pyranones and unsaturated γ-ketoesters for the construction of polycyclic bridged pyranofuropyranones. Org. Biomol. Chem., 2024,22, 496 .    DOI:10.1039/d3ob01862h.

  7. Sagar S. Thorat, Sagar P. Shimpi, Pooja I. Sambherao, Gamidi R. Krishna and Ravindar Kontham. Regioselective Synthesis of Benzannulated [5,6]-Oxaspirolactones via Cu(II)-Catalyzed Cycloisomerization of 2‑(5- Hydroxyalkynyl)benzoates. J. Org. Chem. 2023, DOI: https://doi.org/10.1021/acs.joc.3c01751.

  8. Digamber A. Kambale, Balasaheb R. Borade, Ramavath Vinodkumar and Ravindar Kontham. Divergent Synthesis of Oxepino-Phthalides and [5,5]-Oxaspirolactones through [2 + 2 + 2]- and [2 + 3]-Annulation of Alkynyl Alcohols with α-Ynone-Esters J. Org. Chem. 2023, 88, 12597-12612, DOI: https://doi.org/10.1021/acs.joc.3c01301

  9. V. D. Navale, B. R. Borade, G. Rama Krishna, K. R. Vamkudoth, and R. Kontham. Metabolites from Lactococcus lactis subsp. lactis: Isolation, Structure Elucidation, and Antimicrobial Activity. ACS Omega, 2023, https://doi.org/10.1021/acsomega.3c01662

  10. Priyanka Kataria, Shubhranshu Shekhar Sahoo, and Ravindar Kontham. Bi(III)-Catalyzed Synthesis of Substituted Furans from Hydroxy-oxetanyl Ketones: Application to Unified Total Synthesis of Shikonofurans J, D, E, and C. J. Org. Chem. 2023, 88, 7328-7346. DOI: https://doi.org/10.1021/acs.joc.3c00549.

  11. M. S. Pratapure and R. Kontham. Bismuth (III)-catalyzed cascade condensation of alkynyl alcohols with terminal alkynes: A facile construction of propargyl cyclic ethers. Tetrahedron Lett. 2023, 114, 154724. DOI: https://doi.org/10.1016/j.tetlet.2022.154274.

  12. R. Nomula; M. S. Pratapure; R. Kontham. Studies Directed Toward the Total Synthesis of Nannocystin A. ChemistrySelect. 2022, 7 (42), e202203893. DOI: https://doi.org/10.1002/slct.202203893.

  13. Borade, B. R.; Kontham, R. Concise Total Synthesis of (+)-Lanceolactone A: Revision of Absolute Stereochemistry J. Org. Chem., 2022, 87, 12867-12876.  https://doi.org/10.1021/acs.joc.2c0145

  14. Khan, A.; Said, M. S.; Borade, B. R.; Gonnade, R.; Barvkar, V.; Kontham, R.; Dastager, S. G. Enceleamycins A–C, Furo-Naphthoquinones from Amycolatopsis sp. MCC0218: Isolation, Structure Elucidation, and Antimicrobial Activity. J. Nat. Prod.,2022, 85, 1267- 1273. https://doi.org/10.1021/acs.jnatprod.1c01160.

  15. Mankad, Y.; Thorat, S. S.; Das, P.; Gamidi, R. K.; Kontham, R.; Reddy D. S. Ready Access to Benzannulated [5,5]-Oxaspirolactones Using Au(III)-Catalyzed Cascade Cyclizations. J. Org. Chem. 2022, 87, 3025―3041. DOI:https://doi.org/10.1021/acs.joc.1c02843.

  16. Nakate, A. K.; Thorat, S. S.; Jain, S.; Gamidi, R.; Vanka, K.; Kontham R. Silver-catalyzed [3+3]-annulation cascade of alkynyl alcohols and α,β-unsaturated ketones for the regioselective assembly of chromanes. Org. Chem. Front. 2022, 9, 802―809. DOI:https://doi.org/10.1039/D1QO01643A.

  17. Kataria, P.; Nomula R.; Kontham R. Studies directed toward the synthesis of hedycoropyrans: total synthesis of des-hydroxy (-)-hedycoropyran B (ent-rhoiptelol B). Org. Biomol. Chem. 2022, 20, 444―463. DOI:doi.org/10.1039/D1OB01972D.

  18. Thorat, S. S., Gamidi R.; Kontham R. Stereoselective Total Synthesis of (±)-Pleurospiroketals A and B. J. Org. Chem. 2021, 86, 13572―13582. DOI:10.1021/acs.joc.1c01634.

  19. Kambale, D. A.; Borade, B. R.; Kontham, R. Bismuth(III)-catalyzed bis-cyclization of propargylic diol-esters: a unified approach for the synthesis of [5,5]- and [6,5]-oxaspirolactones. Org. Biomol. Chem. 2021, 19, 6618―6622. DOI:10.1039/D1OB00974E.

  20. Thorat, S. S.; Kontham, R. Strategies for the synthesis of furo-pyranones and their application in the total synthesis of related natural products. Org. Chem. Front. 2021, 8, 2110―2162. DOI:org/10.1039/D0QO01421D.

  21. Borade, B. R.; Dixit, R.; Kontham, R. Total Synthesis of Beshanzuenone D and Its Epimers and Abiespiroside A. Org. Lett. 2020, 22, 8561―8565. DOI://dx.doi.org/10.1021/acs.orglett.0c03157.

  22. Palange, M. N.; Gonnade, R. G.; kontham, R. TiCl4-n-Bu3N-mediated cascade annulation of ketones with α-ketoesters: a facile synthesis of highly substituted fused γ-alkylidene-butenolides. Org. Biomol. Chem. 2019, 17, 5749―5759. https://doi.org/10.1039/C9OB00649D.

  23. Thorat, S. S.; kontham, R. Recent advances in the synthesis of oxaspirolactones and their application in the total synthesis of related natural products. Org. Biomol. Chem. 2019, 17, 7270―7292. DOI:10.1039/c9ob01212e.

  24. Borade, B. R.; Nomula, R.; Gonnade, R. G.; kontham, R. Fe(III)-Catalyzed Diastereoselective Friedel–Crafts Alkylation–Hemiketalization–Lactonization Cascade for the Synthesis of Polycyclic Bridged 2-Chromanol Lactones. Org. Lett. 2019, 21, 2629―2633.  DOI:10.1021/acs.orglett.9b00614.

  25. Thorat, S. S.; Palange, M. N.; kontham, R. Four-Step Total Synthesis of (+)-Yaoshanenolides A and B. ACS Omega  2018, 3, 7036―7045. DOI:10.1021/acsomega.8b00701.

  26. Nakate, A. K.; Pratapure, M.; Kontham, R. Bismuth(III)-catalyzed cycloisomerization and (hetero)arylation of alkynols: a simple access to 2-(hetero)aryl tetrahydrofurans and tetrahydropyrans. Org. Biomol. Chem. 2018, 16, 3229―3240. DOI:10.1039/C8OB00368H.

  27. Thorat, S. S.; Kataria, P.; kontham, R. Synthesis of Furo[2,3-b]pyran-2-ones through Ag(I)- or Ag(I)–Au(I)-Catalyzed Cascade Annulation of Alkynols and α-Ketoesters. Org. Lett. 2018, 20, 872―875. DOI:10.1021/acs.orglett.7b04027.

  28. Kambale, D. A.; Thorat, S. S.; Pratapure, M.; Gonnade, R. G.; kontham, R. Lewis acid catalyzed cascade annulation of alkynols with α-ketoesters: A facile access to γ-spiroketal-γ-lactones. Chem Commun. 2017, 53, 6641―6644. DOI:10.1039/C7CC03668J.

  1. Ragam, S.; Kontham, R.; Regina, C.; Pelletier, J.; Deslongchamps, P. Synthesis of the Antiproliferative Agent Hippuristanol and Its Analogues from Hydrocortisone via Hg(II)-Catalyzed Spiroketalization: Structure-Activity Relationship. J. Med. Chem. 2014, 57, 2511―2523. https://doi.org/10.1021/jm401799j.

  2. Kontham, R.; Pierre-Yves, C.; Deslongchamps, P.  Anionic Polycyclization Entry to Tricycles Related to Quassinoids and Terpenoids: A Stereocontrolled Total Synthesis of (+)-Cassaine. J. Org. Chem. 2014, 79, 7979―7990. DOI: 10.1021/jo501122k.

  3.  Yadav, J. S.; Raju, A.; Kontham, R.; Subba Reddy, B. V. A formal stereoselective synthesis of (-)-brevisamide. Tetrahedron Lett., 2013, 54, 3227―3229. https://doi.org/10.1016/j.tetlet.2013.01.134.

  4. Cencic, R.; Robert, F.; Galicia-Vazquez, G.; Malina, A.; Kontham, R.; Somaiah, J Tanaka, R.; Deslongchamps, P.; Pelletier, J. Modifying Chemotherapy Response by Targeted Inhibition of Eukaryotic Initiation Factor 4A. Nature: Blood Cancer Journal., e, 2013, 128, DOI:10.1038/bcj.2013.25.

  5. Zeina, N.; Lukas, E. D.; Marilene, P.; Jennifer, C.; Kontham, R.; Ragam S. Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. BMC Pharmacology and Toxicology. 2013, 14. https://doi.org/10.1186/2050-6511-14-58.

  6. Kontham, R.; Pierre-Yves, C.; Pierre, D. Total Synthesis of (+)-Cassaine Utilizing an Anionic Polycyclization Strategy. Org. Lett. 2013, 15, 6270―6273. https://doi.org/10.1021/ol4030937.

  7. Yadav, J. S.; Raju, A.; Kontham, R.; Subba Reddy, B. V.; Ghamdi, A. A. K. A. The Stereoselective Total Synthesis of Putaminoxin. Synthesis 2012, 44, 585―590. DOI: 10.1055/s-0031-1290156.

  8. Kontham, R.; Yadav, J. S. Studies Directed Towards the Total Synthesis of Polypropionate Natural Products (–)-Ebelactone-A and (–)-Maurenone (PhD Thesis), Monograph. LAP (Lambert Academic Publishing, Germany)., ISBN: 978-3-8484-4958-3, (2011).

  9. Yadav, J. S.; Rao, R. N.; Kumar, B. P.; Ragam S.;  Kontham, R.; Subba Reddy, B. V.; Ghamdi, A. A. K. A. Concise Total Synthesis of (-)-cis-Aerangis Lactone and (-)-cis-Cognac lactone. Synthesis  2011,  19, 3168―3172. DOI: 10.1055/s-0030-1260190.

  10. Yadav, J. S.; Raghavendra Rao, K. V.; Kontham, R.; Subba Reddy, B. V. Total Synthesis of (+)-Bourgeanic Acid Utilizing Desymmetrization Strategy. Eur. J. Org. Chem. 2011,  58―61. https://doi.org/10.1002/ejoc.201001199.

  11. Kontham, R.; Reddy, M. S.; Lindqvist, L.; Pelletier, J.; Deslongchamps, P. Synthesis of the Antiproliferative Agent Hippuristanol and Its Analogues via Suarez Cyclizations and Hg(II)-Catalyzed Spiroketalizations. J. Org. Chem. 2011, 76, 1269―1284. https://doi.org/10.1021/jo102054r.

  12. Kontham, R.; Reddy, M. S.; Deslongchamps, P. A Highly Efficient Access to Spiroketals, Mono-unsaturated Spiroketals and Furans: Hg(II)-Catalyzed Cyclization of Alkyne Diols and Triols. Org. Lett. 2011, 13, 3178―3181. https://doi.org/10.1021/ol201102x.

  13. Yadav, J. S.; Raghavendra Rao, K. V.; Kontham, R.; Subba Reddy, B. V. Total Synthesis of (+)-Aculeatin D and (+)-6-epi-Aculeatin D. Synlett. 2010, 1, 51―54. DOI: 10.1055/s-0029-1218546.

  14. Yadav, J. S.; Raju, A.; Kontham, R.; Subba Reddy, B. V. Stereoselective Total Synthesis of 11-α- and 11- β -Methoxycurvularins. Synthesis 2010, 5, 797 - 802. DOI: 10.1055/s-0029-1218621.

  15. Yadav, J. S.; Chandrakanth, D.; Gopala Rao, Y.; Kontham, R.; Subba Reddy, B. V. The Stereoselective Total Synthesis of (6S)-5,6-dihydro-6-[(2R)-2-hydroxy-6-phenylhexyl]-2H-pyran-2-one via Prins Cyclisation. Helvetica Chimica Acta. 2010, 93, 1432―1438. https://doi.org/10.1002/hlca.200900414.

  16. Yadav, J. S.; Gopala Rao, Y.; Chandrakanth, D.; Kontham, R.; Subba Reddy, B. V. Total Synthesis of Aculeatins A and B from L-Malic Acid. Helvetica Chimica Acta. 2010, 93, 2426―2432. https://doi.org/10.1002/hlca.201000084.

  17. Kontham, R.; Sridhar Reddy, M.; Lindqvist, L.; Pelletier, J.; Deslongchamps, P. Efficient synthetic Approach to Potent Antiproliferative Agent Hippuristanol via Hg(II)-Catalyzed Spiroketalization. Org. Lett. 2010, 12, 4420―4423. https://doi.org/10.1021/ol1019663.

  18. Yadav, J. S.; Srinivasa Rao, T.; Kontham, R.; Subba Reddy, B. V.  Total Synthesis of (+)-Aspicilin from D-Mannitol. Synlett. 2009, 17, 2828―2830. DOI: 10.1055/s-0029-1217974.

  19. Yadav, J. S.; Gopala Rao, Y.; Kontham, R.; Subba Reddy, B. V.; Narsaiah, A. V. Total Synthesis of Xestodecalactone C from L-Malic Acid. Synthesis 2009, 18, 3157―3161. DOI: 10.1055/s-0029-1216938.

  20. Yadav, J. S.; Subba Reddy, B. V.; Raju, A.; Kontham, R.; Narender, R. The Hydroamination of Unactivated Alkenes with Sulfonamides Catalyzed by Phosphomolybdic Acid/SiO2. Lett. Org. Chem. 2008, 5, 651―654. https://doi.org/10.2174/157017808786857471.

  21. Srihari, P.; Kontham, R.; Somaiah, R.; Yadav, J. S. First Concise Total Synthesis of 5-Epi-prelactone B. Synth. Commun. 2008, 38, 1389―1397. https://doi.org/10.1080/00397910801914194.

  22. Yadav, J. S.; Somaiah, R.; Kontham, R.; Chandraiah,  L. Stereoselective total synthesis of (+)-mueggelone, a novel inhibitor of fish development. Tetrahedron Lett. 2008, 49, 2848―2850. DOI: 10.1016/j.tetlet.2008.02.022.

  23. Yadav, J. S.; Subba Reddy, B. V.; Raju, A.; Kontham, R.; Gakul, B. 1-(Chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2,2,2]octane-bis(tetrafluoroborate) as Novel and Efficient Reagent for the Conjugate Addition of Indoles to α,β-Unsaturated Ketones. Chem. Lett. 2007, 36, 1056―1057. https://doi.org/10.1246/cl.2007.1056.

  24. Yadav, J. S.; Subba Reddy, B. V.; Raju, A.; Kontham, R.; Gakul, B. Hydrothiolation of Unactivated Alkynes Catalyzed by Indium(III) Bromide. Chem. Lett. 2007, 36, 1474―1475. https://doi.org/10.1246/cl.2007.1474.

  25. Yadav, J. S.; Kontham, R.; Subba Reddy, B. V. A Formal Stereoselective Synthesis of (–)-Maurenone. Synlett. 2007, 12, 1957―1959. DOI: 10.1055/s-2007-984497.

  1. Kambale, D. A.; Kontham, R. γ-spiroketal-γ–lactones and pharmaceutical composition containing same and process for preparation thereof. WO2018/203346 A1; PCT/IN2018/05026; Publication Date 08-11-2018; EP3619214A1 Filing Date 27-04-2018 (status pending);  R Kontham, DA Kambale US Patent 11,339,174

  2. Thorat, S. S.; Kontham, R. Furo [2, 3-b] pyran-2-one compounds and process for preparation thereof. WO2018/220647 A1; PCT/IN2018/050345; Publication Date 06-12-2018; US2020/0165263, Filing Date 30-May-2018, Publication Date 28-May-2020; European Patent Under Progress;   http://www.freepatentsonline.com/y2020/0165263.html

  3. Agawane, S. B.; Kontham, R.; Giri, A. P.; Kulkarni, M. J.; Kataria, P. Design, synthesis and biological evaluation of novel eugenol derivatives for potent antidiabetic activity. Application number: 202011042458020/0165263. Complete filing date: 29th Sept 2021

  4. Kontham, R.; Chavan, S. P.; Thorat, S. S.; Kadam, A. L. Process for the Preparation of Sacubitril Intermediates. Application number: 2019-INV-026.

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